Kwesi Appiah's side went into the crucial match in Kumasi one point ahead of their visitors knowing that anything other than a defeat would take them through to the third stage of the CAF qualifying section for Brazil 2014.
Ghana take on Japan in the second fixture of the 2013 Kirin Challenge Cup three days after securing a passage to the final qualification round of Brazil 2014.
Japan have already booked their ticket to next year's World Cup and would regard this series of games as an opportunity to ensure their preparedness ahead of the Mundial.
Ghana, whose only defeat in Group D came in the reverse fixture against the 2012 Africa Cup of Nations champions, secured a narrow 2-1 win as Abdul Waris and Kwadwo Asamoah gave them a two-goal lead before Emmanuel Mbola pulled one back for the visitors.
But, while Ghana have another stage of qualifying to go through to seal their place in next year's showpiece, Japan were the first side to reach Brazil after their 1-1 draw with Australia on June 4.
Japan's latest fixture came in a friendly against Guatemala at Nagai Stadium on Friday, goals from Keisuke Honda, Masato Kudo and Yasuhito Endo sweeping aside Sergio Pardo's side, with coach Alberto Zaccheroni afterwards calling on the team to keep up their level of intensity in their next matches.
Alberto Zaccheroni's side has already reaped much from a recent 3-0 win against Guatemala in the ongoing three-nation tournament and would seek more of the same against their African opponents on September 10.
For the Black Stars, Tuesday’s encounter against the Samurai Blue could be an ideal way to ready themselves for the final 2014 World Cup qualification stage in October and November, a play-off against a yet unknown team.
Doubtlessly, either national side would find this game as important as any they have participated in, in recent months.
Injury-wise, Mainz striker Shinji Okazaki has left the Japan squad due to a left knee issue and would not be replaced for the Ghana match. He is the second player to leave the Asian side following Toshihiro Aoyama, who is hospitalised on suspicion of appendicitis.
