After a narrow 1-0 opening day defeat at Liverpool, the Potters have gone on to post back-to-back Premier League wins over Crystal Palace and West Ham, while also beating Walsall 3-1 at home in the Capital One Cup.
Hughes' side will be looking to keep up the feel-good factor against a Manchester City team who also have two league wins under their belt.
Stoke City could move into the Premier League's top four with a win over Manchester City at the Britannia Stadium on Saturday.
Mark Hughes has won two of his first three league matches as Potters boss, including the 1-0 success over West Ham United two weeks ago.
Manchester City, who sit third in the table, went into the international break off the back of a 2-0 victory over Hull City.
New signings Marko Arnautovic and Stephen Ireland could make their Stoke debuts against Manuel Pellegrini's men.
City defender Martin Demichelis, who recently joined the club from Atletico Madrid, will miss the match due to a knee injury.
Recent form
Stoke City: LWW
Manchester City: WLW
Possible starting lineups
Stoke City: Begovic; Huth, Cameron, Shawcross, Pieters; Wilson, Arnautovic, Etherington, Adam; Walters Jones
Manchester City: Hart; Zabaleta, Kolarov, Nastasic, Lescott; Fernandinho, Toure, Silva; Aguero, Negredo, Navas
These both came at home - a 4-0 drubbing of Newcastle and 2-0 victory over Hull City last time.
But Manuel Pellegrini's side have yet to win on the road this term after a shock 3-2 defeat at Premier League new-boys Cardiff City.
Without the injured Vincent Kompany for their last two games, Pellegrini's team have looked shaky in defence and Hughes will be aiming to exploit any weaknesses against the club who dismissed him in December 2009.
Paul Merson's prediction
I watched Stoke against West Ham on Soccer Saturday and I thought they were brilliant, passing the ball about nicely, so I'm backing them to go away from this game with a draw. I say that because Man City are really struggling for defenders and I fear for them in the centre-half position.
