Gaston Ramirez was impressive in that game but is a doubt after limping off.
Crystal Palace will be without Damien Delaney due to an ankle injury but midfielder Kagisho Dikgacoi could earn a recall after serving his suspension.
Paddy McCarthy and Yannick Bolasie remain out however with respective groin and hamstring injuries.
Southampton should be full of confidence heading into a home date with a Crystal Palace side yet to get going.
The Saints rolled the dice in terms of transfer business over the summer, opting to spend big in an effort to further consolidate their top flight standing.
Considerable investment has provided an immediate return, with eight points from their opening five fixtures taking them above the likes of Manchester United, Swansea City and Newcastle United in the Premier League table.
Mauricio Pochettino was charged with the task of building on the foundations put down by his predecessor Nigel Adkins when he inherited the managerial reins, and the Argentine has done just that - with a dogged defensive unit having been breached just two times so far.
The one concern for the Saints, and a glimmer of hope for Palace, is that Dejan Lovren's winner at Liverpool last time out saw Southampton find the target for just the third time in the league.
Ian Holloway's side have also struggled for goals though - drawing a blank in their last two matches and three out of five so far.
Southampton
Boruc, Shaw, Lovren, Fonte, Clyne, Wanyama, Schneiderlin, Rodriguez, Osvaldo, Lallana, Lambert
Crystal Palace
Speroni, Moxey, Mariappa, Guédioura, Gabbidon, Ward, Jedinak, Dikgacoi, Jerome, Gayle, Chamakh
