Diego Simeone and Los Rojiblancos meanwhile hope to open up a gap between themselves and 3rd place Madrid. Atletico have won all six of their first league matches this season and are behind Barcelona only on goal differential at the moment.
This will be the first meeting between the two teams since last season's Copa Del Rey final which was won by Atletico, their first victory over their local rivals since 1999.
Real Madrid injuries and suspensions
Out: Xabi Alonso (foot), Raphaël Varane (knee), Marcelo (thigh).
Atletico Madrid injuries and suspensions
Out: Adrian (fractured cheekbone).
Both teams are mostly healthy with Xabi Alonso being Madrid's only sidelined player as he continues to recover from foot surgery. Varane and Marcelo are both training and nearing their returns to the lineup. For Atletico, Adrian remains out with a fractured bone in his face.
Projected lineups
Real Madrid: Diego López, Álvaro Arbeloa, Pepe, Sergio Ramos, Fábio Coentrão, Sami Khedira, Asier Illarramendi, Gareth Bale, Isco, Cristiano Ronaldo, Karim Benzema.
Atletico Madrid: Thibaut Courtois, Juanfran, João Miranda, Diego Godín, Emilano Insúa, Mario Suárez, Tiago Mendes, Arda Turan, Koke, Diego Costa, David Villa.
Match Date/Time: 10 p.m. local, 4:00 p.m. ET
Venue: Estadio Santiago Bernabéu, Madrid, Spain
