As things stand, the pair currently sit on four points and six points in UEFA Group A, respectively, and a loss for either side would be enough to rule out any hopes of making it to Brazil next summer.
A win is absolutely vital for the desperate duo and three points on Friday could lift the victors to third place in the standings, although goal difference makes that less likely for the hosts.
Bale joined the squad in Cardiff on Monday following his world-record £86 million transfer to the Bernabeu, but having not played for Tottenham since July, Coleman says he is unwilling to throw his star performer in at the deep end.
Wales' chances may be hampered somewhat as a result, with Bale having scored five of his country's last eight goals, but Coleman will not be taking any chances with the former Spurs man.
"We are aware a lot of people will want to see him play in the home game against Serbia [on Tuesday].
"But he has no chance of playing 90 minutes on Friday or on Tuesday."
Newcastle United defender Paul Dummett could be in line for a senior debut after featuring for his club side against Manchester City this season, while Cardiff City teenager Declan john is also in the squad for the first time.
Dummett's chances of appearing were boosted as Swansea City left-back Neil Taylor was forced to pull out of the squad due to a thigh injury. Joe Allen (hamstring) and Neil Eardley (knee) were also forced to withdraw.
For Macedonia, Aleksandar Todorovski misses out on a place in the squad due to injury, while Stefan Sprivoski has been left out due to a lack of playing time, having failed to feature for his club side, Borac Cacak of Serbia, so far this season.
Central defender Boban Grncarov returns, as do left-back Aleksandar Lazevski and attacking midfielder Darko Tasevski.
When: Friday, Sept. 6, kickoff at 6 p.m. BST
Where: Philip II Arena, Skopje, Republic of Macedonia
