Manager Andre Villas-Boas is likely to make a number of changes to his usual starting lineup for the Premier League, with Jermain Defoe in line to start up front if Roberto Soldado is rested.
Tottenham kick off their Europa League Group K campaign with a home clash with Norwegian side Tromso on Thursday night (8.05pm).
Spurs reached the quarter-finals of the competition last season and they will be looking to improve on that this term.
Andre Villas-Boas' side have started the Premier League season well with three wins from four games, but the Portuguese is expected to make a number of changes to his side for the Europa League.
Wingers Aaron Lennon (foot) and Nacer Chadli (hip) are both ruled out through injury, while midfielder Etienne Capoue is sidelined with an ankle problem.
Jermain Defoe could be in line for a rare start, but Emmanuel Adebayor is not in the first-team plans of Villas-Boas and continues to train with the development squad.
Romanian defender Vlad Chiriches could also make his debut in a white shirt.
Spurs have begun their Premier League campaign with three wins from four and currently lie third, level on points with North London rivals Arsenal.
Tromso, meanwhile, have not had a good season in the Eliteserien, which is nearing its close, and occupy 13th place in the 16-team league, meaning that they have relegation worries as well as a European campaign to worry about.
Their victory over Besiktas in qualifying for the group stage was one of the shocks of the European season and will mean that Spurs should not treat them lightly at White Hart Lane.
Spurs: Friedel; Walker, Kaboul, Chiriches, Naughton; Townsend, Sandro, Sigurdsson, Holtby, Kane; Defoe
Tromso: Sahlman; Fojut, Koppinen, Norbye, Ciss; Bendiksen, Drage, Andersen, Johansen; Moldskred, Ondrasek
