The hosts suffered a disappointing home defeat to Basel on Wednesday night and will be looking to bounce back in the league against their local rivals.
Chelsea captain John Terry is likely to return after being rested in midweek.
Ramires sat out Wednesday's defeat by Basel through suspension but is available for domestic action, while Juan Mata will hope to earn a recall.
It will have been a long week for Jose Mourinho, which will have reminded him once again that he has inherited a very different Chelsea squad to the one he left six years ago.
Darren Bent is fit for Fulham but fellow forward Dimitar Berbatov will have a fitness test on a hamstring problem.
Bryan Ruiz's ankle injury means he joins Aaron Hughes, Matthew Briggs and Maarten Stekelenburg on the sidelines.
Fulham made the perfect start to their season with three points at Sunderland, but have failed to win in their three games since.
Blues manager Jose Mourinho has no injury or suspension concerns for the game, but could opt to drop one or two of the players who disappointed on Wednesday.
Dimitar Berbatov is expected to return from the injury he picked up against West Bromwich Albion, but Darren Bent and Bryan Ruiz will most likely miss out for the Cottagers.
Chelsea: Cech; Ivanovic, Cahill, David Luiz, Cole; Oscar, Lampard, Ramires; Mata, Hazard, Eto'o
Fulham: Stockdale; Riether, Senderos, Hangeland, Richardson; Duff, Sidwell, Parker, Kacaniklic; Kasami; Berbatov
