The midfielder moved to the Bernabeu from Real Sociedad in July, but failed to make an appearance in pre-season as he recovered from muscle injuries sustained during the European Under-21 Championship, which he helped Spain win.
However, he took part in full training ahead of the game and will be a useful boost to Carlo Ancelotti's midfield numbers.
Xabi Alonso (foot) and Sami Khedira (knee) have been absent from training recently, with the former definitely ruled out.
Khedira limped out of Madrid's narrow 2-1 win over Betis last week and is likely to be replaced by Brazilian Casemiro, who came on in his place in the home victory.
Raphael Varane remains unavailable for selection due to a knee injury sustained at the end of last season, leaving Sergio Ramos and Pepe as the only senior centre-backs available to Ancelotti.
Isco is likely to continue in the creative hub for Madrid after scoring their late winner last week. Jorge Molina had given the Andalusian side a 14th-minute lead before Karim Benzema equalised shortly afterwards.
A frustrating game for Madrid looked to be heading for a draw, until the former Malaga man nodded home on his home debut in the dying embers.
Granada also kicked off their league campaign with a 2-1 success, impressively turning over Osasuna away from home.
As Dennis previewed in his scouting report, Granada acquired the services of some key players this summer. According to Sid Lowe in Real Madrid TV's latest episode of The Match, only 13 players from last season's Granada squad remain with the club. Therefore, Real Madrid should look to strike early to destabilize what may very well be a team-in-progress.
Ancelotti has called up the following players for the clash:
REAL MADRID LINE-UP
Goalkeepers: Casillas, Diego López and Tomás Mejías.
Defenders: Pepe, Sergio Ramos, Arbeloa, Nacho, Marcelo and Carvajal.
Midfield: Kaká, José Rodríguez, Özil, Modric, Casemiro, Isco and Di María.
Forwards: Cristiano Ronaldo, Benzema, Jesé and Morata.
Ancelotti has not revealed who will start between the posts. Looking at the defensive line, it's possible that Arbeloa may start ahead of Carvajal at right back. Carvajal started Real Madrid's first match partially because Arbeloa had been away on international duty earlier that week, so Ancelotti may start Arbeloa to see how he responds to the opportunity. The rest of the defensive line is easy to predict: Sergio Ramos, Pepe and Marcelo.
Due to injuries to Sami Khedira, Illaramendi and Xabi Alonso, Luka Modric will start in the heart of midfield likely partnered by Brazilian youngster Casemiro. Isco and Mesut Özil will likely start in the attacking midfield, although expect Angel Di María to get significant minutes in this match. Road games tend to be gritty and combative, and against a stubborn Granada side Ancelotti may require Di María's pace both on attack and defense. Kaká looked sluggish and unconvincing during Raul's testimonial match, so it's unlikely #8 will see any action.
