Malky Mackay's newly-promoted Bluebirds will be looking to bounce back after losing their first game of top-flight football in 51 years last Saturday.
The 2-0 defeat at West Ham came after goals from Joe Cole and Kevin Nolan in either half.
The Bluebirds need to pick up points quickly and, to add extra spice to the occasion, veteran Craig Bellamy comes up against his old side.
But it will be tough to get the win the home fans desire against a Manchester City side who will be full of confidence following their 4-0 demolition of Newcastle on Monday.
New boss Manuel Pellegrini was impressed with his players and called on his side to continue to play "aggressive" football against the Bluebirds.
He said: "We tried to play 90-minute football (against the Magpies). I am sure the players are enjoying this way and we will try to continue.
"It was just one match but it is very important to continue this way and at the end of the season, we will see who has won the title."
Cardiff City injuries and suspensions
Out: None. In doubt: Andreas Cornelius (ankle).
Manchester City injuries and suspensions
Out: Vincent Kompany (groin). In doubt: Matija Nastasić (ankle), Micah Richards (hamstring) and Stevan Jovetić (knock).
Projected lineups
Cardiff City: David Marshall; Declan John, Ben Turner, Steven Caulker, Matthew Connolly; Craig Bellamy, Peter Whittingham, Gary Medel, Bo-Kyung Kim, Aron Gunnarsson; Andreas Cornelius
Manchester City: Joe Hart; Gaël Clichy, Joleon Lescott, Matija Nastasić, Pablo Zabaleta; Fernandinho, Yaya Touré; David Silva, Sergio Agüero, Jesús Navas; Edin Džeko
Match Date/Time: Sunday, 4 p.m. local, 11 a.m. ET
Venue: Cardiff City Stadium, Cardiff, Wales
