Juan Mata's late winner at Old Trafford on Sunday put the Blues three points clear of fifth-placed Spurs, and another similar result would put Rafael Benitez's men within touching distance of a guaranteed top-four finish.
Chelsea's superior goal difference gives them a further edge in the battle for a Champions League spot, but a Tottenham win would throw the race wide open.
Chelsea v Tottenham
May 8, 2013 7:00pm
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However, Andre Villas-Boas takes his side to his former employers trying to break one of the longest-standing records in Premier League history.
In 20 visits to Stamford Bridge in the Premier League era, Spurs have never emerged victorious.
No other club has such a record in the top flight, and despite enjoying a successful debut season at White Hart Lane, Villas-Boas could end up missing out on Champions League if they do not pick up something in west London.
As ever, Gareth Bale is likely to be Tottenham's main threat on Wednesday night.
He has netted 11 in his last 11 matches, and has scored 13 goals away from home this season - more than any other player.
